The Mitochondrial Death Pathway and Cardiac Myocyte Apoptosis
نویسندگان
چکیده
منابع مشابه
Cardiac myocyte apoptosis.
Apoptosis, or programmed cell death, is an energy dependent process that effects the controlled removal of a cell. The process is activated during tissue development, such that unneeded structures may be removed and tissues can be shaped and sculpted. It is also activated in response to cellular injury and results in the removal of the injured cell without damaging surrounding tissue. The proce...
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Sympathetic nerve activity increases in the heart during cardiac failure. Here, we hypothesized that 1 integrins play a protective role in chronic -adrenergic receptor–stimulated cardiac myocyte apoptosis and heart failure. L-isoproterenol (iso; 400 g/kg per hour) was infused in a group of wild-type (WT) and 1 integrin heterozygous knockout (hKO) mice. Left ventricular structural and functional...
متن کاملThe mitochondrial death pathway.
Mitochondria have long been known to be critical for cell survival due to their role in energy metabolism. However, not until the mid-1990s did it become evident that mitochondria are also active participants in programmed cell death (PCD). This chapter focuses mainly on the role the mitochondria in mammalian cell death and cancer progression and therapy.
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Acknowledgments Our work is supported by grants from the Centre National de la Recherche Scientifique, the Agence Nationale pour la Recherche sur le SIDA, the Association pour la Recherche sur le Cancer, the Fondation pour la Recherche Médicale, the European Commission (QLG1-CT-1999-00739), the Ligue Nationale contre le Cancer, and the Ministry of Science. The authors thank Aurélien Deniaud for...
متن کاملSignaling Pathways in Cardiac Myocyte Apoptosis
Cardiovascular diseases, the number 1 cause of death worldwide, are frequently associated with apoptotic death of cardiac myocytes. Since cardiomyocyte apoptosis is a highly regulated process, pharmacological intervention of apoptosis pathways may represent a promising therapeutic strategy for a number of cardiovascular diseases and disorders including myocardial infarction, ischemia/reperfusio...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 2004
ISSN: 0009-7330,1524-4571
DOI: 10.1161/01.res.0000148632.35500.d9